Proton pump inhibitors overuse: only inappropriate prescriptions or further iatrogenic damage?

Use and overuse of proton pump inhibitors

In 2009, an editorial by Putman focused on the dramatic increase in the use of proton pump inhibitors (PPIs) in infants [1]. Considering the increasing evidence that PPIs offer little benefit for most of the symptoms for which they are prescribed, Putman strongly highlighted the need for a serious effort to curtail their empiric use. The editorial was linked to a study by Orenstein et al, which...

Overuse and inappropriate prescribing of proton pump inhibitors in patients with Clostridium difficile-associated disease.

BACKGROUND Clostridium difficile is the most common infectious cause of colitis and has been increasingly diagnosed in hospitalized patients. The number of prescriptions for proton pump inhibitors (PPIs) has also increased significantly over time. Few studies have reported an association between C. difficile-associated disease (CDAD) and PPI use. AIM To assess the extent and appropriateness o...

Inappropriate use of proton pump inhibitors, guidelines and clinical research.

Inappropriate prescribing of proton pump inhibitors in hospitalized patients.

BACKGROUND Proton pump inhibitors have numerous important side effects, yet they are prescribed for outpatients who do not have recognized indications. Less is known with respect to prescribing for inpatients. OBJECTIVE To determine the rate of inappropriate prescribing of protein pump inhibitors and to assess reasons why they are prescribed. DESIGN AND PARTICIPANTS The study was a retrospe...

Proton Pump Inhibitors: Omeprazole